Plasma Ubiquinoneto UbiquinolRatio in Patients with Hepatitis, Cirrhosis, and Hepatoma, and in Patients Treated with Percutaneous Transluminal Coronary Reperfusion

Scientists found a loss of Ubiquinol with subjects that have certain types of liver disease. Certain liver conditions are also known to have elevated oxidative stress, as witnessed by the increase in biomarkers such as TBARS (serum thiobarbituric acid reactive substances).

Researchers at the University of Tokyo showed that patients with hepatitis, cirrhosis, and hepatoma all exhibited a decrease in the Ubiquinol ratio percent, while the total levels of amounts of CoQ10 (Ubiquinol + Ubiquinone) was not reduced. These studies demonstrate that as the level of oxidative stress increases, the ratio of the Ubiquinol:Ubiquinone declines. This is both an indication that these type of physical states particularly require Ubiquinol and provides support for the use of the ratio as a biomarker of oxidative stress.

Journal: Biofactors 1999; 9(2-4):241-6.

Authors: Yamamoto Y, Yamashita S

Department: Research Center for Advanced Science and Technology, University of Tokyo, Japan

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