Effect of licorice on the reduction of body fat mass in healthy subjects

The history of licorice, as a medicinal plant, is very old and has been used in many societies throughout the millennia.

The active principle, glycyrrhetinic acid, is responsible for sodium retention and hypertension, which is the most common side-effect. We show an effect of licorice in reducing body fat mass. Licorice was able to reduce body fat mass and to suppress aldosterone, without any change in BMI. Since the subjects were consuming the same amount of calories during the study, we suggest that licorice can reduce fat by inhibiting 11β-hydroxysteroid dehydrogenase Type 1 at the level of fat cells.

Journal: Journal of Endocrinological Investigation

Authors: D. Armanini, C. B. De Palo, M. J. Mattarello, P. Spinella, M. Zaccaria, A. Ermolao, M. Palermo, C. Fiore, P. Sartorato, F. Francini-Pesenti, I. Karbowiak


Department of Medical and Surgical Sciences-Endocrinology, University of Padua, Padova, Italy

Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy

Department of Endocrinology, University of Sassari, Sassari, Italy

Department of Clinical Pathology, Piove di Sacco, Padua, Italy

Abstract Link: https://www.ncbi.nlm.nih.gov/pubmed/14594116