Levels of Reduced And Oxidized Coenzymeq-10 And 8-Hydroxy-2 - Deoxyguanosinein the Cerebrospinal Fluid of Patients with Living Parkinson’s Disease Demonstrate That Mitochondrial Oxidative Damage and/or Oxidative DNA Damage Contributes to the Neurodegenera

Researchers from Iwate Medical University in Japan examined Ubiquinone and Ubiquinol levels in the cerebrospinal fluid from a small number of untreated Parkinson’s disease patients, in order to ascertain the oxidative balance.

There was no correlation between the content of Ubiquinone (oxidized CoQ10) and age of the patients. However, the Parkinsonʼs Disease patients did have higher concentrations of Ubiquinone relative to the control group, and the %CoQ10 (which is the percentage of Ubiquinone to Total CoQ10) was also higher. This shift from the Ubiquinol to the Ubiquinone form may mark the extent of oxidative stress and, conversely, the level of antioxidant protection.

Journal: Neuroscience Letters

Authors: Isobe T, Abe T, Terayama Y

Department: Department of Neurology, Iwate Medical University, 19-1 Uchimaru, Morioka, Iwate 020-0805, Japan

Abstract link: http://www.ncbi.nlm.nih.gov/pubmed/19944739