Hypoglycemic Effects of Glabridin, a Polyphenolic Flavonoid from Licorice, in an Animal Model of Diabetes Mellitus

The present study was designed to investigate the hypoglycemic effects of Glabridin from licorice in an animal model of diabetes mellitus (DM).

Male Kunming mice were used to induce DM using streptozotocin (STZ). The data obtained showed that Glabridin significantly increased body weight, glucose tolerance and SOD activities in the liver, kidney and pancreas, while decreasing FBG levels and MDA content in the liver, kidney and pancreas. These results demonstrated that Glabridin possesses hypoglycemic effects.

Journal: Molecular Medicine Reports

Authors: Feihua Wu, Zhigui Jin, Jian Jin

Department: Department of Pharmacy, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Huangpu, Shanghai 200011, China

Abstract link: www.spandidos-publications.com/10.3892/mmr.2013.1330