The researchers conducted broad genome expression profiling in various tissues (liver, kidney, heart and brain) of SAMP1 mice supplemented with Ubiquinol or Ubiquinone. The scientists detected the presence of redox-sensitive genes, specifically Ubiquinol-dependent gene networks that are involved in inflammation and lipid metabolism.

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Based on the initial study published in 2008, Dr. Langsjoen expanded the number of patients on Ubiquinol. For a variety of markers associated with cardiovascular function ranging from plasma CoQ10 levels to ejection fraction, the Ubiquinol form showed better benefit with less amounts required.

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An initial group of subjects with end stage congestive heart failure (NYHA Class IV) were being given an average of 450 mg per day of Ubiquinone. Despite the supplemental Ubiquinone, blood values were a mean of 1.6 mcg/mL plasma.

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