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Supplementation with the Reduced Form of Coenzyme Q10 Decelerates Phenotypic Characteristics of Senescence and Induces a Peroxisome Proliferator Activated Receptor-Alpha Gene Expression Signature in SAMP1 Mice
The researchers conducted broad genome expression profiling in various tissues (liver, kidney, heart and brain) of SAMP1 mice supplemented with Ubiquinol or Ubiquinone. The scientists detected the presence of redox-sensitive genes, specifically Ubiquinol-dependent gene networks that are involved in inflammation and lipid metabolism.