Supplementation with the Reduced Form of Coenzyme Q10 Decelerates Phenotypic Characteristics of Senescence and Induces a Peroxisome Proliferator Activated Receptor-Alpha Gene Expression Signature in SAMP1 Mice

The researchers conducted broad genome expression profiling in various tissues (liver, kidney, heart and brain) of SAMP1 mice supplemented with Ubiquinol or Ubiquinone. The scientists detected the presence of redox-sensitive genes, specifically Ubiquinol-dependent gene networks that are involved in inflammation and lipid metabolism.

These Ubiquinol sensitive genes involved in cholesterol and lipid metabolism were not affected by Ubiquinone. The research also indicated that, in comparison to Ubiquinone, Ubiquinol supplementation was more effective at increasing total CoQ10 levels in the liver.

Journal: Molecular Nutrition and Food Research

Authors: Schmelzer C, Kubo H, Mori M, Sawashita J, Kitano M, Hosoe K, Boomgaarden I, Doring F, Higuchi K

Department: Institute of Human Nutrition and Food Science, Molecular Prevention, Christian-Albrechts-University of Kiel, Heinrich-Hecht-Platz 10, Kiel, Germany

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