Impact of Oral Ubiquinol on Blood Oxidative Stress and Exercise Performance

Coenzyme Q10 (CoQ10) plays an important role in bioenergetic processes and has antioxidant activity.

To test the hypothesis fifteen exercise-trained individuals (10 men and 5 women; 30-65 years) were given reduced CoQ10 (Kaneka QH Ubiquinol; 300 mg per day) or a placebo for four weeks in a random order, double blind, cross-over design (3 week washout). Treatment with CoQ10 resulted in a significant increase in total blood CoQ10 (138%; P = 0.02) and reduced blood CoQ10 (168%; P = 0.02), but did not improve exercise performance (with the exception of selected individuals) or impact oxidative stress. The relationship between the percentage change in total blood CoQ10 and the cycle sprint total work (R(2) = 0.6009) was noted to be moderate to strong.

Journal: Oxidative Medicine and Cellular Longevity

Authors: Richard J. Bloomer, Robert E. Canale, Cameron G.McCarthy, and Tyler M. Farney

Department: Cardiorespiratory-Metabolic Laboratory, The University of Memphis, Memphis, TN 38152, USA

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